代表性论文: 1. Chen Y*, Huang LY, Zhang HY, Diao XL, Zhao SY, Zhou WK. Reduction in autophagy by (-)-Epigallocatechin-3-3Gallate (EGCG): a potential mechanism of prevention of mitochondrial dysfunction after subarachnoid hemorrhage. Mol Neurobiol2017, 54(1): 392-405. (二区 IF 6.19) 2. Chen Y*, Chen JJ, Sun XX, Shi XX, Wang L, Huang LY, Zhou WK. Evaluation ofthe neuroprotective effect of EGCG: a potential mechanism of mitochondrial dysfunction and mitochondrial dynamics after subarachnoid hemorrhage. Food Funct 2018, 9(12): 6349-6359. (一区) 3. Chen Y*, Huang LY, Wang L, Chen LY, Ren WH, Zhou WK. Differential expression of microRNAs contributed to the health efficacy of EGCG in in vitro subarachnoid hemorrhage model. Food Funct 2017, 8: 4675-4683. (一区) 4. Chen Y*, Huang LY, Zhang HY, Sun HY, Zhou WK. EGCG protective mitochondrial dysfunction after subarachnoid haemorrhage via inhibition p38α pathway. J Funct Foods 2016, 23: 115-123. (一区) 5. Zhang YY, Han MG, Sun XX, Gao GJ, Yu GY, Huang LY, Chen Y*. EGCG promotes neurite outgrowth through the integrin β1/FAK/p38 signaling pathway after subarachnoid hemorrhage. Evid Based Complement Alternat Med 2021, 2021:8810414. 6. Miao YH,Sun XX, Gao GJ, Jia XL, Wu H, Chen Y, Huang LY. Evaluation of(-)-epigallocatechin-3-gallate (EGCG)-induced cytotoxicity on astrocytes: A potential mechanism of calcium overloading-induced mitochondrial dysfunction.Toxicology in Vitro 2019, 61: 104592. 7. Huang LY,Hou YQ,Wang L, Xu XH, Guan QK, Li XS, Chen Y, Zhou WK*. p38 inhibitor protects mitochondrial dysfunction by induction of DJ-1 mitochondrial translocation after subarachnoid hemorrhage. J Mol Neurosci 2018, 66(2): 163-171. 8. Chen Y, Sun HY, Huang LY*, Li JX, Zhou WK, Chang JL.Neuroprotective effect of radix trichosanthis saponins on subarachnoid hemorrhage. Evid Based Complement Alternat Med 2015, 2015: 313657. 9. Chen Y, Miao YH, Huang LY, Li JX, Sun HY, Zhao YZ, Yang J, Zhou WK. Antioxidant activities of saponins extracted from Radix Trichosanthis: an in vivo and invitro evaluation. BMC Complem Altern M 2014, 14: 86. 10. Chen Y, Zhang HY, Yang J, Sun HY. Improved antioxidant capacity of optimization of a self-microemulsifying drug delivery system for resveratrol. Molecules 2015, 20: 21167-21177. 11. Mo HZ,Chen Y*, Huang LY, Zhang H, Li JX, Zhou WK. Neuroprotective effect of tea polyphenols on oxyhemoglobin induced subarachnoid hemorrhage in mice.Oxid Med Cell Longe 2013, 2013: 743938. 12. Huang LY, Wan J, Chen Y, Wang ZW, Hui L, Li Y, Xu DW, Zhou WK*. Inhibitory effects of p38 inhibitor against mitochondrial dysfunction after subarachnoid hemorrhage in mice. Brain Res2013, 1517: 133-140. 13. Chen YH, Chen Y, Huang LY, Yu JB. Evaluation of heparanase and matrix metalloproteinase-9 in patients with cutaneous malignant melanoma. J Dermatol 2012, 39: 339-343. 14. Zhang HY, Chen Y, Fan BL, Wang WF, Zhu WL. Overexpression of VEGF183 promotes murine breast cancer cell proliferation in vitro and induces dilated intratumoral microvessels. Tumor Biol 2015, 36: 3871-3880. 专利成果: 1. 从天花粉中综合提取多种生物活性成分的方法,国家发明专利(授权),ZL201410291925.6 2. 天花粉皂苷及其在制备治疗缺血性脑血管疾病中的应用,国家发明专利(授权),ZL201010537400.8 3. 抗癌药物组合物,国家发明专利(授权),ZL2004100359256 |